Determination of genotoxic effects of copper sulphate and cobalt chloride in Allium cepa root cells by chromosome aberration and comet assays.

@article{Yildiz2009DeterminationOG,
  title={Determination of genotoxic effects of copper sulphate and cobalt chloride in Allium cepa root cells by chromosome aberration and comet assays.},
  author={Mustafa Kemal Yildiz and Ibrahim Hakki Ciğerci and Muhsin Konuk and Abdurrahman Fatih Fidan and Hakan Terzi},
  journal={Chemosphere},
  year={2009},
  volume={75 7},
  pages={934-8}
}
We used the anaphase-telophase chromosome aberration and comet (Single Cell Gel Electrophoresis, SCGE) assays to evaluate the genotoxic effects of copper sulphate (CS) and cobalt chloride (CC) chemicals prepared in two concentrations (EC(50), 2xEC(50)), using methyl methanesulfonate (MMS) as a positive control and untreated cells as a negative control. In Allium root growth inhibition test, EC(50) values for CS and CC are 1.5 and 5.5 ppm, respectively. Mitotic index (MI) decreased in all… CONTINUE READING

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