Determination of gene promoter activity in skeletal muscles in vivo.


The use of nonviral (plasmid DNA) gene delivery into skeletal muscle has increased significantly in recent years. The procedure is used to overexpress wild-type proteins, express mutant proteins, or knock down endogenous proteins. These manipulations can identify the role of a specific protein in muscle cell biology and physiology. The same procedure of… (More)
DOI: 10.1007/978-1-61779-343-1_27


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