Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein.

@article{Mizoguchi2000DeterminationOF,
  title={Determination of functional regions of p125, a novel mammalian Sec23p-interacting protein.},
  author={Toshihide Mizoguchi and Koichi Nakajima and Kiyotaka Hatsuzawa and Masami Nagahama and Hans Peter Hauri and Mitsuo Tagaya and Katsuko Tani},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={279 1},
  pages={144-9}
}
The Sec23p-Sec24p complex is a component of coat protein II-coated vesicles involved in protein export from the endoplasmic reticulum. We previously identified a novel Sec23p-interacting protein, p125, which consists of 1000 amino acids and comprises a proline-rich region and a phospholipase A(1) homology region. p125, when ectopically expressed in cultured cells, localizes to endoplasmic reticulum-Golgi intermediate regions. In the present study we showed that expressed p125 principally… CONTINUE READING