Determination of free valproic acid: evaluation of the Centrifree system and comparison between high-performance liquid chromatography and enzyme immunoassay.

Abstract

Valproic Acid (VPA) is an important drug for the treatment of several types of seizures because it has a wide spectrum of activity. Since VPA has an unusual nonlinear binding characteristic and a wide interindividual variation, monitoring of its free concentration can be helpful in patient management. The determination of unbound VPA is more difficult… (More)

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@article{Liu1992DeterminationOF, title={Determination of free valproic acid: evaluation of the Centrifree system and comparison between high-performance liquid chromatography and enzyme immunoassay.}, author={H. Liu and Jos{\'e} Montoya and Leanne Forman and Catherine Eggers and C F Barham and M. Delgado}, journal={Therapeutic drug monitoring}, year={1992}, volume={14 6}, pages={513-21} }