Determination of folate transport pathways in cultured rat proximal tubule cells.

@article{Sikka1998DeterminationOF,
  title={Determination of folate transport pathways in cultured rat proximal tubule cells.},
  author={Pankaj K. Sikka and Kenneth E. McMartin},
  journal={Chemico-biological interactions},
  year={1998},
  volume={114 1-2},
  pages={15-31}
}
Deficiency of the vitamin folic acid has recently been linked with increased incidence of neural tube defects and of cardiovascular disease, through elevated plasma homocysteine levels. The kidney has an important role in conserving folate to counteract development of deficiency. Urinary folate excretion is regulated by the degree of reabsorption of folate by the proximal tubule cell. To evaluate an in vitro model for studies of the regulation of urinary folate excretion, the present studies… CONTINUE READING