Determination of ethamsylate in pharmaceutical preparations based on an auto-oxidation chemiluminescence reaction.

Abstract

Strong chemiluminescence emission has been observed by mixing alkaline hydrolytic products of ethamsylate with Tween 80 in acidic rhodamine 6G solution. This phenomenon has been utilized to design a flow-injection chemiluminescence method for the determination of ethamsylate in a pharmaceutical preparation. Under the optimum conditions, the proposed procedure has a linear range between 0.05 and 2.0 microg ml(-1), with a detection limit of 0.02 microg ml(-1) for ethamsylate. The method was applied to the determination of ethamsylate in pharmaceutical preparations. The possible mechanism of this chemiluminescence reaction was proposed.

Cite this paper

@article{Yang2002DeterminationOE, title={Determination of ethamsylate in pharmaceutical preparations based on an auto-oxidation chemiluminescence reaction.}, author={Fengzhen Yang and Chao Zhang and W. R. G. Baeyens and Xinrong Zhang}, journal={Journal of pharmaceutical and biomedical analysis}, year={2002}, volume={30 3}, pages={473-8} }