Determination of enriched histone modifications in non-genic portions of the human genome

  title={Determination of enriched histone modifications in non-genic portions of the human genome},
  author={Jeffrey A. Rosenfeld and Zhibin Wang and Dustin E. Schones and Keji Zhao and Robert DeSalle and Michael Q Zhang},
  journal={BMC Genomics},
  pages={143 - 143}
Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) has recently been used to identify the modification patterns for the methylation and acetylation of many different histone tails in genes and enhancers. We have extended the analysis of histone modifications to gene deserts, pericentromeres and subtelomeres. Using data from human CD4+ T cells, we have found that each of these non-genic regions has a particular profile of histone modifications that distinguish it… CONTINUE READING


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