Determination of endogenous levels of GHB in human hair. Are there possibilities for the identification of GHB administration through hair analysis in cases of drug-facilitated sexual assault?

@article{Goull2003DeterminationOE,
  title={Determination of endogenous levels of GHB in human hair. Are there possibilities for the identification of GHB administration through hair analysis in cases of drug-facilitated sexual assault?},
  author={Jean Pierre Goull{\'e} and Marjorie Ch{\`e}ze and Gilbert P{\'e}pin},
  journal={Journal of analytical toxicology},
  year={2003},
  volume={27 8},
  pages={574-80}
}
We have developed a GC-MS-MS assay for GHB in human hair. Five milligrams of washed hair were hydrolyzed by 1M or 0.01M NaOH before a liquid-liquid extraction with ethyl acetate under acidic conditions. GHB-d(6) was used as the internal standard. TMS derivatives were formed before injection. TBDMS derivatives were used in cases of strong chromatographic interferences or in a confirmatory procedure. Analysis of basal levels of GHB in 61 drug-free donors gave the following results: the mean… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Apropos de deux cas d'utilisation originale de la soumission chimique

  • G. Ppin, Y. Gaillard
  • 9~me CongrEs de la Soci~t~ Franqaise de…
  • 2001

Disposition of GHB after oral controlled administration

  • P. Kintz, V. Cirimele, J. P. Goull, B. Ludes
  • Treffen der Oberrheinischen Rechtsmediziner…
  • 2001

La soumission chimique. Aspects analytiques et expertises m~dico-I~gales

  • P. Kintz
  • 9~me Congrbs de la Soci~t~ Fran(~aise de…
  • 2001

Similar Papers

Loading similar papers…