Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo.

@article{Bertocchini2004DeterminationOE,
  title={Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo.},
  author={Federica Bertocchini and Isaac Skromne and Lewis Wolpert and Claudio D Stern},
  journal={Development},
  year={2004},
  volume={131 14},
  pages={
          3381-90
        }
}
Avian embryos have a remarkable capacity to regulate: when a pre-primitive streak stage embryo is cut into fragments, each fragment can spontaneously initiate formation of a complete embryonic axis. We investigate the signalling pathways that initiate primitive streak formation and the mechanisms that ensure that only a single axis normally forms. As reported previously, an ectopic primitive streak can be induced by misexpression of Vg1 in the marginal zone. We now show that Vg1 induces an… CONTINUE READING

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