Determination of effective concentrations of drug absorption enhancers using in vitro and ex vivo models.

  title={Determination of effective concentrations of drug absorption enhancers using in vitro and ex vivo models.},
  author={Poloko Stephen Kheoane and G M Enslin and Clemence Tarirai},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},



A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability

A biopharmaceutics drug classification scheme for correlating in vitro drug product dissolution and in vivo bioavailability is proposed based on recognizing that drug dissolution and gastrointestinal

Evaluation of liposomal curcumin cytochrome p450 metabolism.

Based on preliminary data, liposomal curcumin will not interact with other chemotherapy agents that are metabolized and/or eliminated via the primary drug metabolizing CYP450 pathways.

Potential risks resulting from fruit/vegetable-drug interactions: effects on drug-metabolizing enzymes and drug transporters.

It is concluded that the knowledge of the potential risk of nutrient-drug interactions is still limited and efforts to elucidate potential risks resulting from food- drug interactions should be intensified in order to prevent undesired and harmful clinical consequences.

Herb–drug pharmacokinetic interactions reviewed

As the incidence and severity of herb–drug pharmacokinetic interactions increase due to a worldwide rise in the use of herbal preparations, more clinical data regarding herb– drug pharmacokinetics interactions are needed to make informed decisions regarding patient safety.

Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin.

  • Jun-shik ChoiB. JoYoun-Chul Kim
  • Biology, Chemistry
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2004

Effects of dietary fruits, vegetables and a herbal tea on the in vitro transport of cimetidine: Comparing the Caco-2 model with porcine jejunum tissue

The excised porcine jejunum model seemed to provide a more realistic estimation of botanical-drug pharmacokinetic interactions than the Caco-2 cell model, which is congruent with findings from previous studies.

Effects of Kampo medicines on P-glycoprotein.

The inhibitory effect of the Kampo medicines on the ATPase activity correlated with their licorice root (kanzo) content, suggesting the contribution of licorICE root in the P-gp inhibition.