Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors.

@article{Laginha2005DeterminationOD,
  title={Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors.},
  author={Kimberley M Laginha and Sylvia Verwoert and Gregory J. R. Charrois and Theresa M. Allen},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 19 Pt 1},
  pages={6944-9}
}
PURPOSE Pharmacokinetic studies on liposomal drugs have previously measured total drug levels in tumors, which include non-bioavailable drug. However, drugs must be released from liposomes to have activity. We have developed a method for measuring levels of bioavailable (released) doxorubicin in vivo in tumors that will allow therapeutic activity to be correlated with bioavailable drug levels. EXPERIMENTAL DESIGN Mice orthotopically implanted with mammary carcinoma (4T1) were injected i.v. 10… CONTINUE READING
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Pharmacoki - netics of pegylated liposomal doxorubicin : review of animal and human studies

  • A Gabizon, H Shmeeda, BarenholzY
  • Clin Pharmacokinet
  • 2003

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