Determination of doxorubicin and metabolites in murine specimens by high-performance liquid chromatography.

@article{Asperen1998DeterminationOD,
  title={Determination of doxorubicin and metabolites in murine specimens by high-performance liquid chromatography.},
  author={J. van Asperen and Olaf van Tellingen and Jos H. Beijnen},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={1998},
  volume={712 1-2},
  pages={129-43}
}
A sensitive and selective reversed-phase high-performance liquid chromatographic method for the quantification of doxorubicin and its metabolites doxorubicinol, 7-deoxydoxorubicinone and 7-deoxydoxorubicinolone was developed and validated for a variety of murine specimens. Daunorubicin was used as internal standard. Sample pretreatment involved liquid-liquid extraction of 200 microl sample with 1 ml of chloroform-1-propanol (4:1, v/v). Chromatographic separation was achieved isocratically on a… CONTINUE READING

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