Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection.

@article{Hu2003DeterminationOD,
  title={Determination of dissociation constants of anthrocycline by capillary zone electrophoresis with amperometric detection.},
  author={Qin Hu and Gang Hu and Tianshu Zhou and Yuzhi Fang},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2003},
  volume={31 4},
  pages={679-84}
}
Although daunorubicin, pharmorubicin and idarubicin are important drugs in medical and in pharmaceutical research, the dissociation constants (K(a)) of these substances are frequently not known. A method based on a non-linear model enabling the efficient determination of the K(a) of the three drugs by capillary zone electrophoresis with amperometric detection (CZE-AD) has been demonstrated. The pK(a) values obtained through the method were in agreement with the values by typical… CONTINUE READING