Determination of diphenoxylate hydrochloride and atropine sulfate in combination drug formulations by liquid chromatography.

@article{Lehr1996DeterminationOD,
  title={Determination of diphenoxylate hydrochloride and atropine sulfate in combination drug formulations by liquid chromatography.},
  author={Gary J Lehr},
  journal={Journal of AOAC International},
  year={1996},
  volume={79 6},
  pages={1288-93}
}
  • Gary J Lehr
  • Published 1996 in Journal of AOAC International
An isocratic, reversed-phase liquid chromatographic (LC) method was developed for simultaneous determination of diphenoxylate hydrochloride (I) and atropine sulfate (II) in pharmaceutical products. Analysis is conducted on a Spherisorb CN column (5 microns), with a mobile phase consisting of 47% 0.001M pentanesulfonic acid sodium salt monohydrate, 53… CONTINUE READING