Determination of dimethylarginine levels in rats using HILIC-MS/MS: an in vivo microdialysis study.

@article{Zotti2008DeterminationOD,
  title={Determination of dimethylarginine levels in rats using HILIC-MS/MS: an in vivo microdialysis study.},
  author={Margherita Zotti and Stefania Schiavone and Filomena Tricarico and Marilena Colaianna and Oceania D'Apolito and Giuseppe Paglia and Gaetano Corso and Luigia Trabace},
  journal={Journal of separation science},
  year={2008},
  volume={31 13},
  pages={2511-5}
}
Nitric oxide (NO) is one of the most important mediators and neurotransmitters and its levels change under pathological conditions. NO production may be regulated by endogenous nitric oxide synthase (NOS) inhibitors, in particular asymmetric dimethylarginine (ADMA). Most of the interest is focused on ADMA, since this compound is present in plasma and urine and accumulation of ADMA has been described in many disease states but little is known about cerebrospinal fluid (CSF) concentrations of… CONTINUE READING