Determination of dextromethorphan metabolizer phenotype in healthy volunteers

  title={Determination of dextromethorphan metabolizer phenotype in healthy volunteers},
  author={Michael Hildebrand and Wilfried Seifert and A. Reichenberger},
  journal={European Journal of Clinical Pharmacology},
The dextromethorphan metabolizer phenotype in 450 healthy volunteers (299 men, 151 women) was determined after oral administration of a 15 mg dose. In 8 h-postdose urine samples the ratio of dextrorphan (DOP) to dextromethorphan (DMP) was measured by HPLC. Urinary excretion of DMP and DOP within 8 h after the dose varied greatly between individuals, ranging from 0–11% and 0.04–100% of dose, respectively. In 143 test subjects the fraction of the dose of DMP in urine was below the detection limit… CONTINUE READING

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