Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship.

Abstract

The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several clinically important drugs. So far more than 50 different CYP2D6 allelic variants have been described, and thus there is an increased need for routine high-performance liquid chromatography (HPLC) methods for the evaluation of the functional implication of… (More)

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Cite this paper

@article{Dorado2005DeterminationOD, title={Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship.}, author={Pedro Dorado and Roland Berecz and Macarena C. C{\'a}ceres and Idilio Gonz{\'a}lez and Jes{\'u}s Cobaleda and Adri{\'a}n Llerena}, journal={Clinical chemistry and laboratory medicine}, year={2005}, volume={43 3}, pages={275-9} }