Determination of creatinine in urine by tandem mass spectrometry.

  title={Determination of creatinine in urine by tandem mass spectrometry.},
  author={Ren{\'a}ta H{\'u}skov{\'a} and Petr Chrastina and Tom{\'a}{\vs} Adam and Petr Schneiderka},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  volume={350 1-2},
BACKGROUND Electrospray tandem mass spectrometry (TMS) is a very powerful tool that enables one to perform high sample throughput analysis. This paper describes a method to determine creatinine in urine by tandem mass spectrometry with direct sample infusion into an ion source. METHODS Samples (50 microl) were diluted with internal standard (IS) (450 microl of 0.667 mmol/l deuterated creatinine). Diluted samples were introduced into mass spectrometer with no prior pretreatment and after… CONTINUE READING

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