Determination of conformational changes in the progesterone receptor using ELISA-like assays

@article{Pullen2006DeterminationOC,
  title={Determination of conformational changes in the progesterone receptor using ELISA-like assays},
  author={M. Pullen and N. Laping and R. Edwards and J. Bray},
  journal={Steroids},
  year={2006},
  volume={71},
  pages={792-798}
}
The conformation of proteins often influences their functional activity. The effect of progesterone receptor ligands on the C-terminal conformation of the progesterone receptor affects the recruitment of transcriptional cofactors. These conformations can be studied by differential sensitivity to proteolytic cleavage or immunoprecipitation with a conformation-specific antibody. This study describes an ELISA-like method using conformation-specific antibodies to the C-terminal or an area adjacent… Expand
11-(pyridinylphenyl)steroids--a new class of mixed-profile progesterone agonists/antagonists.

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