Determination of common structural features in Escherichia coli promoters by computer analysis.

@article{Lisser1994DeterminationOC,
  title={Determination of common structural features in Escherichia coli promoters by computer analysis.},
  author={S P Lisser and Hanah Margalit},
  journal={European journal of biochemistry},
  year={1994},
  volume={223 3},
  pages={823-30}
}
Escherichia coli promoters show a large degree of sequence variation. However, they are all recognized specifically by RNA polymerase as the sites for transcription initiation, suggesting that they share common basic structural features distinguishing them from the rest of the sequence. Our hypothesis is that the promoter is determined not only by the two consensus sequences at -10 and -35, but also by the surrounding nucleotides, and that it is not only the identity of the nucleotides that is… CONTINUE READING