Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma.

@article{Kaijser1993DeterminationOC,
  title={Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma.},
  author={Gerry Kaijser and Jos H. Beijnen and E L Jeunink and Auke Bult and Hj. Keizer and Jan de Kraker and Willy J. M. Underberg},
  journal={Journal of chromatography},
  year={1993},
  volume={614 2},
  pages={
          253-9
        }
}
A derivatization high-performance liquid chromatographic method with ultraviolet detection to monitor the plasma concentration of chloroacetaldehyde, a neurotoxic metabolite of oxazaphosphorine drugs, is presented. To prevent the rapid degradation of chloroacetaldehyde, the plasma samples are stabilized with formaldehyde. The method is linear in the concentration range 1-250 nmol/ml. Blood samples from a patient who was treated with a ten-day continuous infusion of ifosfamide were assayed. The… CONTINUE READING

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