Determination of celecoxib in human plasma and rat microdialysis samples by liquid chromatography tandem mass spectrometry.

@article{Brutigam2001DeterminationOC,
  title={Determination of celecoxib in human plasma and rat microdialysis samples by liquid chromatography tandem mass spectrometry.},
  author={Lutz Br{\"a}utigam and Gregor Vetter and Irmgard Tegeder and Georg Heinkele and Gerd 7 Geisslinger},
  journal={Journal of chromatography. B, Biomedical sciences and applications},
  year={2001},
  volume={761 2},
  pages={203-12}
}
Methods for the determination of celecoxib in human plasma and rat microdialysis samples using liquid chromatography tandem mass spectrometry are described. Celecoxib and an internal standard were extracted from plasma by solid-phase extraction with C18 cartridges. Thereafter compounds were separated on a short narrow bore RP C18 column (30 x 2 mm). Microdialysis samples did not require extraction and were injected directly using a narrow bore RP C18 column (70 x 2 mm). The detection was by a… CONTINUE READING

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