Determination of catecholamines and their 3-O-methylated metabolites in urine by mass fragmentography with use of deuterated internal standards.

@article{Muskiet1979DeterminationOC,
  title={Determination of catecholamines and their 3-O-methylated metabolites in urine by mass fragmentography with use of deuterated internal standards.},
  author={Frits A. J. Muskiet and C G Thomasson and Alie M Gerding and D C Fremouw-Ottevangers and Gentiana Nagel and Bert G. Wolthers},
  journal={Clinical chemistry},
  year={1979},
  volume={25 3},
  pages={453-60}
}
We report the determination of catecholamines (dopamine, norepinephrine, and epinephrine) and their 3-O-methylated metabolites (3-methoxytyramine, normetanephrine, and metanephrine) in urine by gas chromatography/mass spectrometry, with use of stable isotopically labeled internal standards. Normal excretion values in terms of creatinine, expressed as a function of age, are given, together with results obtained for patients with neuroblastoma, ganglioneuroblastoma, pheochromocytoma, parkinsonism… CONTINUE READING

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