Determination of carbohydrate-deficient transferrin in human serum with capillary zone electrophoresis. Sample preparation strategies for the removal of interferences caused by increased levels of immunoglobulins.

@article{Lanz2008DeterminationOC,
  title={Determination of carbohydrate-deficient transferrin in human serum with capillary zone electrophoresis. Sample preparation strategies for the removal of interferences caused by increased levels of immunoglobulins.},
  author={Christian J Lanz and Jean-Bernard Falmagne and François de l'Escaille and Ulrich Marti and Wolfgang Thormann},
  journal={Journal of chromatography. A},
  year={2008},
  volume={1206 1},
  pages={33-40}
}
Capillary zone electrophoresis (CZE) in fused-silica capillaries is an effective analytical approach for the separation and determination of the transferrin (Tf) isoforms and thus carbohydrate-deficient transferrin (CDT) in human serum. Sera of patients with progressed liver cirrhosis are prone to interferences in the beta region which prevent the proper determination of CDT by CZE without additional sample preparation. Efforts to identify, reduce or even eliminate these interferences have been… CONTINUE READING