Determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry employing precolumn derivatization.

Abstract

A sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method was developed to determine carbocysteine in human plasma using 2-pyridylacetic acid as the internal standard (IS). The method employed derivatization with 10 M hydrochloric acid/methanol, which significantly improved the ionization efficiency of carbocysteine. After methanol… (More)

Topics

Cite this paper

@article{Chen2003DeterminationOC, title={Determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry employing precolumn derivatization.}, author={Xiaoyan Chen and Da-fang Zhong and Ying Han and Zhiyong Xie}, journal={Rapid communications in mass spectrometry : RCM}, year={2003}, volume={17 3}, pages={192-6} }