Determination of carbamazepine and its metabolite carbamazepine-10,11-epoxide in serum with gas-chromatography mass spectrometry.

@article{Minkova2001DeterminationOC,
  title={Determination of carbamazepine and its metabolite carbamazepine-10,11-epoxide in serum with gas-chromatography mass spectrometry.},
  author={Galya D Minkova and Damianka P. Getova},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2001},
  volume={23 9},
  pages={
          481-5
        }
}
Carbamazepine, one of the most often used antiepileptic drugs, undergoes enzyme biotransformation through epoxidation with the formation of its metabolite, carbamazepine-10,11-epoxide (carbamazepine epoxide). The determination of carbamazepine epoxide is clinically significant in therapeutic drug monitoring as it decreases the risk of toxic reactions and increases the possibility of reaching the expected therapeutic result. The aim of this study was to introduce a gas chromatographic method… CONTINUE READING
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