Determination of bromhexine as its trifluoroacetyl derivative by gas-liquid chromatography with electron-capture detection.

@article{leenheer1979DeterminationOB,
  title={Determination of bromhexine as its trifluoroacetyl derivative by gas-liquid chromatography with electron-capture detection.},
  author={A P De leenheer and L M Vandecasteele-Thienpont},
  journal={Journal of chromatography},
  year={1979},
  volume={175 2},
  pages={301-6}
}
A specific gas-liquid chromatographic method with electron-capture detection is described for the determination of bromhexine at the nanogram level. Structurally analogous internal standards were synthesized and their suitability was investigated, based on their chromatographic properties on different stationary liquid phases. The electron-capture activity of the compounds is increased by trifluoroacetylation. Reaction conditions for this derivatization were studied. Calibration graphs in the… CONTINUE READING