Determination of bradykinin-(1–5) in inflammatory exudate by a new ELISA as a reliable indicator of bradykinin generation

@article{Majima1996DeterminationOB,
  title={Determination of bradykinin-(1–5) in inflammatory exudate by a new ELISA as a reliable indicator of bradykinin generation},
  author={Masataka Majima and Kyoko Nishiyama and Yusuke Iguchi and K Yao and Mitsuharu Ogino and Tetsuji Ohno and Noriyuki Sunahara and Kansei Katoh and Nobuhiro Tatemichi and Y. Takei and Makoto Katori},
  journal={Inflammation Research},
  year={1996},
  volume={45},
  pages={416-423}
}
We have developed an ELISA for BK-(1–5) (Arg1-Pro2-Pro3-Gly4-Phe5). In rat carrageenin-induced pleurisy, in which a plasma exudation peak was observed 5 h after carrageenin, BK levels in the exudates were negligible (<60 pg/rat). BK-(1–7) (des-Phe8-Arg9-BK) was detectable (900–400 pg/rat) over the entire course of the inflammation. However, a larger amount of BK-(1–5) was detectable in association with the increase in plasma exudation, showing a peak (8800±1200 pg/rat) 3 h after carrageenin… CONTINUE READING

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