Determination of bifendate in human plasma by HPLC-MS and bioequivalence on bifendate pills in healthy volunteers.


A sensitive and specific method for the determination of bifendate in human plasma was developed, based on high-performance liquid chromatography (HPLC)-mass spectrometry (MS). The samples were extracted from plasma with diethyl ether, followed by separation and evaporation after addition of internal standard diazepam. The residue was reconstituted in… (More)