Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood.

@article{Tsukahara2008DeterminationOA,
  title={Determination of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, in umbilical blood.},
  author={Hirokazu Tsukahara and Naoko Ohta and Shuko Tokuriki and Koji Nishijima and Fumikazu Kotsuji and Hisako Kawakami and Norihito Ohta and Kyouichi Sekine and Hironori Nagasaka and Mitsufumi Mayumi},
  journal={Metabolism: clinical and experimental},
  year={2008},
  volume={57 2},
  pages={215-20}
}
Endothelial cells produce nitric oxide (NO), a potent vasodilator. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase. Little is known about the potential physiological roles of ADMA in a perinatal setting. This study measures concentrations of ADMA in umbilical blood using enzyme-linked immunosorbent assay and those of NO as nitrite/nitrate (NOx(-)) using the Griess assay. Their relationship to the degree of prematurity and maternal clinical condition is examined… CONTINUE READING