Determination of appropriate stage of human-induced pluripotent stem cell-derived cardiomyocytes for drug screening and pharmacological evaluation in vitro.

@article{Shinozawa2012DeterminationOA,
  title={Determination of appropriate stage of human-induced pluripotent stem cell-derived cardiomyocytes for drug screening and pharmacological evaluation in vitro.},
  author={Tadahiro Shinozawa and Kenichi Imahashi and Hiroshi Sawada and Hatsue Furukawa and Kenji Takami},
  journal={Journal of biomolecular screening},
  year={2012},
  volume={17 9},
  pages={1192-203}
}
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) at different stages (approximate days 30, 60, and 90) were used to determine the appropriate stage for functional and morphological assessment of drug effects in vitro. The hiPS-CMs had spontaneous beating activity, and β-adrenergic function was comparable in all stages of differentiation. Microelectrode array analyses using ion channel blockers indicated that the electrophysiological properties of these ion channels were… CONTINUE READING

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