Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays

@article{Hacia1999DeterminationOA,
  title={Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays},
  author={Joseph G. Hacia and Jian-Bing Fan and Oliver A. Ryder and Li Jin and Keith Edgemon and G. Ghandour and R Aeryn Mayer and Bryan Sun and Linda Hsie and Christiane M. Robbins and Lawrence C. Brody and David G. Wang and Eric S. Lander and Robert J. Lipshutz and Stephen P. A. Fodor and Francis S. Collins},
  journal={Nature Genetics},
  year={1999},
  volume={22},
  pages={164-167}
}
Here we report the application of high-density oligonucleotide array (DNA chip)-based analysis to determine the distant history of single nucleotide polymorphisms (SNPs) in current human populations. We analysed orthologues for 397 human SNP sites (identified in CEPH pedigrees from Amish, Venezuelan and Utah populations) from 23 common chimpanzee, 19 pygmy chimpanzee and 11 gorilla genomic DNA samples. From this data we determined 214 proposed ancestral alleles (the sequence found in the last… Expand
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