Determination of alosetron in human plasma or serum by high-performance liquid chromatography with robotic sample preparation.

@article{Lloyd1996DeterminationOA,
  title={Determination of alosetron in human plasma or serum by high-performance liquid chromatography with robotic sample preparation.},
  author={Thomas L. Lloyd and Suresh Kumar Gupta and Ann Gooding and J R Alianti},
  journal={Journal of chromatography. B, Biomedical applications},
  year={1996},
  volume={678 2},
  pages={261-7}
}
A method of analysis for the determination of alosetron in human plasma or serum has been developed. The method was fully automated using a laboratory robot in order to improve analytical precision, efficiency and safety. The assay involved solid-phase extraction with reversed-phase HPLC separation and fluorescence detection. A validation exercise over the concentration range of 0.1 to 20 ng/ml demonstrated the selectivity, linearity, sensitivity, accuracy, precision, extraction efficiency… CONTINUE READING

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