Determination of adamantane derivatives in pharmaceutical formulations by using spectrophotometric UV-Vis method

  title={Determination of adamantane derivatives in pharmaceutical formulations by using spectrophotometric UV-Vis method},
  author={A. Sobczak and I. Muszalska and Paulina Rohowska and Tomasz Inerowicz and Hubert Dotka and A. Jelińska},
  journal={Drug Development and Industrial Pharmacy},
  pages={657 - 661}
A simple and sensitive extractive spectrophotometric method have been developed and validated for determination of amantadine hydrochloride (AM), memantine hydrochloride (MM) and rimantadine hydrochloride (RM) in pure and pharmaceutical formulations. The method is based on the reaction of these active compounds with bromophenol blue (BB) in acetate buffer (0.1 M) pH 3.5 to form an orange-colored products which have absorption maxima at 408 nm. The procedure of complexation was optimized with… Expand
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