Determination of aconitine in body fluids by LC-MS-MS

@article{Beike2004DeterminationOA,
  title={Determination of aconitine in body fluids by LC-MS-MS},
  author={Justus Beike and Lara Frommherz and Michelle Wood and Bernd Brinkmann and Helga K{\"o}hler},
  journal={International Journal of Legal Medicine},
  year={2004},
  volume={118},
  pages={289-293}
}
A very sensitive and specific method was developed for the determination of aconitine, the main toxic alkaloid from plants of the genus Aconitum L., in biological samples. The method comprised solid-phase extraction using mixed-mode C8 cation exchange columns followed by liquid chromatography-tandem mass spectrometry (LC-MS-MS). Chromatographic separation was achieved with a RP8 column. Detection of aconitine was achieved using electrospray in the positive ionisation mode and quantification was… 
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Results indicate that the developed method is suitable for the determination of aconitine analogues in Aconitum plants and foods that cause food poisoning.
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TLDR
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Rapid determination of yunaconitine and related alkaloids in aconites and aconite-containing drugs by ultra high-performance liquid chromatography-tandem mass spectrometry.
TLDR
A rapid and sensitive ultra high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) detection combined with microwave-assisted extraction (MAE) was developed for high throughput simultaneous determination of YAC and six other toxic aconite alkaloids in 31 samples of crude, processed aconites and aconite-containing drugs.
Hidden aconite poisoning: identification of yunaconitine and related aconitum alkaloids in urine by liquid chromatography-tandem mass spectrometry.
TLDR
Yunaconitne, a highly toxic aconitum alkaloid, was thus identified in human urine for the first time and is an important diagnostic aid for acute poisoning by aconites of an unclear origin.
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