Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology.

@article{Dagerhamn2008DeterminationOA,
  title={Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology.},
  author={Jessica Dagerhamn and Christel Blomberg and Sarah Browall and Karin Sj{\"o}str{\"o}m and Eva Morfeldt and Birgitta Henriques-Normark},
  journal={Journal of clinical microbiology},
  year={2008},
  volume={46 3},
  pages={863-8}
}
Relatedness between isolates of Streptococcus pneumoniae can be determined from sequences of multiple genes belonging to the core genome (multilocus sequence typing [MLST]), but these do not provide information on gene content that may affect the potential of isolates to cause invasive pneumococcal disease. Gene content data, obtained using microarrays, were gathered for 40 clinical isolates of 12 serotypes belonging to 30 multilocus sequence types. We found that sequence variations in… CONTINUE READING

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