Determination of a common genetic variant of luteinizing hormone using DNA hybridization and immunoassays.

@article{Nilsson1998DeterminationOA,
  title={Determination of a common genetic variant of luteinizing hormone using DNA hybridization and immunoassays.},
  author={Carin H. Nilsson and Mei-hua Jiang and Knut Pettersson and Antti Iiti{\"a} and Miia M{\"a}kel{\"a} and Henrik Simonsen and Simon Easteal and R. J. Herrera and Ilpo Tapani Huhtaniemi},
  journal={Clinical endocrinology},
  year={1998},
  volume={49 3},
  pages={
          369-76
        }
}
OBJECTIVE An immunologically anomalous form of LH, due to two point mutations in codons 8 and 15 of the LH beta gene, has previously been described. LH status, i.e. the discrimination between wild-type (WT) and variant (V) LH, is usually determined by immunoassays, which can be unreliable at low serum concentrations of LH. A DNA hybridization assay was therefore developed to score the LH genotype in all subjects, independent of their serum LH concentrations. To evaluate the performance of the… CONTINUE READING

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