Determination of Sample Size for Two Stage Sequential Designs in Bioequivalence Studies under 2x2 Crossover Design

@inproceedings{Fenta2014DeterminationOS,
  title={Determination of Sample Size for Two Stage Sequential Designs in Bioequivalence Studies under 2x2 Crossover Design},
  author={Haile Mekonnen Fenta},
  year={2014}
}
Sequential design is an adaptive design that allows for pre-mature termination of a trial due to efficacy or futility based on the interim analyses. The concept of sequential statistical methods was originally motivated by the need to obtain clinical benefits under certain economic constraints. That is for a trial for a positive results, early stopping ensures that a new drug product can exploited sooner, while negative results indicated, early stopping avoids wastage of resources. In short… CONTINUE READING

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