Determination of Parthenolide from Dissolution Testing of Powdered Feverfew Products

@article{Chapman2015DeterminationOP,
  title={Determination of Parthenolide from Dissolution Testing of Powdered Feverfew Products},
  author={R. Chapman and Karen M NagelEdwards},
  journal={Pharmacy \& Pharmacology International Journal},
  year={2015},
  volume={2}
}
Botanical dietary supplements are widely available without requirements for proof of safety or efficacy, but with requirements to be produced according to current Good Manufacturing Practices. Since 2007, cGMP’s mandated under federal law include standards for manufacture, storage and distribution and the assurance of quality and integrity of products sold to consumers. While standards require compliance with content claims made in labeling, there remain no assurances of bioavailability… Expand

References

SHOWING 1-10 OF 12 REFERENCES
Challenges with Dissolution Testing and Quality Assessment for Commercial Feverfew Products
The purpose of this study was to develop a suitable dissolution test for feverfew products and to investigate the parthenolide content, disintegration, and dissolution performance of several marketedExpand
Variations in parthenolide content and daily dose of feverfew products.
  • Michael H. Nelson, S. Cobb, Jon Shelton
  • Chemistry, Medicine
  • American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  • 2002
TLDR
Large variations were observed in the parthenolide contents and daily intake as recommended by the labeling in commercial feverfew products. Expand
Parthenolide Content and Bioactivity of Feverfew (Tanacetum parthenium (L.) Schultz‐Bip.). Estimation of Commercial and Authenticated Feverfew Products
TLDR
It is suggested that manufacturers of feverfew products should use measurements of parthenolide as a means of standardization and quality control, since therapeutic efficacy has only been demonstrated for preparations of Feverfew that contain parthensolide. Expand
Selected Physical and Chemical Properties of Feverfew (Tanacetum parthenium) Extracts Important for Formulated Product Quality and Performance
TLDR
The results suggested that feverfew extracts deformed mainly plastically, and extract manufactures should commit to proper quality control procedures that ensure accurate label claims, and supplement manufacturers should take into account possible differences in physico-chemical properties when using extracts from multiple suppliers. Expand
Herbal medicines in migraine prevention Randomized double-blind placebo-controlled crossover trial of a feverfew preparation.
TLDR
A prophylactic effect could not be demonstrated for the feverfew preparation, but the patients seemed to have a tendency to use fever symptomatic drugs during the period they used feverfew. Expand
A review of 12 commonly used medicinal herbs.
TLDR
A review of the data on 12 of the most commonly used herbs in the United States is provided and practical information and guidelines for the judicious use of medicinal herbs are provided. Expand
THE UNITED STATES PHARMACOPEIAL CONVENTION
To the Editor. —I was much interested in your editorial regarding the Pharmacopeial convention. I think you were quite right in making it "hot" but it seems to me that your wrath was directed in theExpand
1527-1531
  • Citation: Chapman RL, Edwards KMN
  • 2015
USP38-NF33. United States Pharmacopeial Convention
  • 2015
Feverfew
  • Hosp Pharm
  • 1999
...
1
2
...