Determination of In Vitro Activities of Solithromycin at Different pHs and Its Intracellular Activity against Clinical Isolates of Neisseria gonorrhoeae from a Laboratory Collection.

@article{Mallegol2013DeterminationOI,
  title={Determination of In Vitro Activities of Solithromycin at Different pHs and Its Intracellular Activity against Clinical Isolates of Neisseria gonorrhoeae from a Laboratory Collection.},
  author={Julia Mallegol and Prabhavathi B Fernandes and Christine Seah and Cyril Guyard and Roberto G Melano},
  journal={Antimicrobial agents and chemotherapy},
  year={2013},
  volume={57 9},
  pages={4322-4328}
}
We evaluated the activity of solithromycin against 196 clinical gonococcal isolates collected at the Public Health Ontario Laboratories, Toronto, Canada, including isolates with different levels of azithromycin resistance, as well as the role of pH in MIC determinations using pH-adjusted agar plates (pH range, 5.6 to 7.6). In vitro invasion assays were performed using monolayers of HeLa epithelial cells and clinical gonococci displaying different azithromycin MICs; infected cultures were… CONTINUE READING

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