Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages.

@article{Song2017DeterminationOH,
  title={Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages.},
  author={Gina Song and Xueying Sun and Ronald N Hines and Deborah Gail McCarver and Brian G Lake and Thomas G. Osimitz and Moire R Creek and Harvey J. Clewell and Miyoung Yoon},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2017},
  volume={45 5},
  pages={
          468-475
        }
}
Predicting age-specific metabolism is important for evaluating age-related drug and chemical sensitivity. Multiple cytochrome P450s and carboxylesterase enzymes are responsible for human pyrethroid metabolism. Complete ontogeny data for each enzyme are needed to support in vitro to in vivo extrapolation (IVIVE). This study was designed to determine age-dependent human hepatic CYP2C8 expression, for which only limited ontogeny data are available, and to further define CYP1A2 ontogeny. CYP2C8 and… CONTINUE READING

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