Determination of HER2 gene amplification in breast cancer using dual-color silver enhanced in situ hybridization (dc- SISH) and comparison with fluorescence ISH (FISH).

@article{Unal2013DeterminationOH,
  title={Determination of HER2 gene amplification in breast cancer using dual-color silver enhanced in situ hybridization (dc- SISH) and comparison with fluorescence ISH (FISH).},
  author={Betul Unal and Fatma Seyda Karaveli and Hadice Elif Peştereli and Gulgun Erdogan},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2013},
  volume={14 10},
  pages={6131-4}
}
BACKGROUND The two basic methods that are currently accepted to identify the HER2 status are immunohistochemistry and flyorescence in situ hybridization (FISH) . The aim of this study was to perform the dual-color silver in situ hybridization (dc-SISH) technique as an alternative to FISH. MATERIALS AND METHODS A total of 40 invasive breast carcinoma cases were assessed for HER2 gene amplification by FISH and dual- color SISH. RESULTS Significant correlation was found in the HER2 expression… CONTINUE READING
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6134 breast cancer using tissue microarrays : correlation between chromogenic ( CISH ) and automated silver - enhanced ( SISH ) methods with patient outcome

  • A Gschwind, OM Fischer, A Ullrich
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