Determination of GHB in urine and serum by LC/MS using a simple one-step derivative.

@article{Kaufmann2007DeterminationOG,
  title={Determination of GHB in urine and serum by LC/MS using a simple one-step derivative.},
  author={Eckhard Kaufmann and Andreas H Alt},
  journal={Forensic science international},
  year={2007},
  volume={168 2-3},
  pages={133-7}
}
A sensitive and specific method for the determination of gamma-hydroxybutyric acid (GHB) in urine and serum is described. Prior to quantification by LC/MS in a Pauli-type ion trap, the molecule is converted by a fast and simple one-step procedure into its n-butyl ester derivative. Hexa-deutero GHB has been used as internal standard. 

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