• DOI:10.1016/0378-4347(93)80273-7
Corpus ID: 36045595

Determination of Elsamitrucin (BMY-28090) in plasma and urine by high-performance liquid chromatography with fluorescence detection.

@article{Klein1993DeterminationOE,
  title={Determination of Elsamitrucin (BMY-28090) in plasma and urine by high-performance liquid chromatography with fluorescence detection.},
  author={I. Klein and J. Welink and W. van der Vijgh},
  journal={Journal of chromatography},
  year={1993},
  volume={622 2},
  pages={
          249-53
        }
}

• I. Klein, J. Welink, W. van der Vijgh
• Published 1993
• Chemistry, Medicine
• Journal of chromatography

The cytostatic agent Elsamitrucin is a new fermentation product active in a variety of in vivo tumor models of murine and human origin. To determine its pharmacokinetics during the clinical phase I trial, an HPLC procedure was developed and validated. Plasma samples were extracted after addition of the internal standard, i.e. the analog Chartreusin. Urine samples were injected without extraction of the samples. Because of the wide concentration range of Elsamitrucin in the plasma samples two… Expand

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