Determination of EGFR mutations in single cells microdissected from enriched lung tumor cells in peripheral blood.

@article{Ran2013DeterminationOE,
  title={Determination of EGFR mutations in single cells microdissected from enriched lung tumor cells in peripheral blood.},
  author={Ran Ran and Long-Yun Li and Mengzhao Wang and Shulan Wang and Zhi Zheng and Peter Ping Lin},
  journal={Analytical and bioanalytical chemistry},
  year={2013},
  volume={405 23},
  pages={7377-82}
}
A minimally invasive and repeatable approach for real-time epidermal growth factor receptor (EGFR) mutation surveillance would be highly beneficial for individualized therapy of late stage lung cancer patients whose surgical specimens are often not available. We aim to develop a viable method to detect EGFR mutations in single circulating tumor cells (CTCs). Using a model CTC system of spiked tumor cells in whole blood, we evaluated EGFR mutation determination in single tumor cells enriched… CONTINUE READING
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