Determination of EGFR Signaling Output by Opposing Gradients of BMP and JAK/STAT Activity

  title={Determination of EGFR Signaling Output by Opposing Gradients of BMP and JAK/STAT Activity},
  author={Mariana Fregoso Lomas and Scott De Vito and Jean-François Boisclair Lachance and J. Houde and L. Nilson},
  journal={Current Biology},
  • Mariana Fregoso Lomas, Scott De Vito, +2 authors L. Nilson
  • Published 2016
  • Biology, Medicine
  • Current Biology
  • A relatively small number of signaling pathways drive a wide range of developmental decisions, but how this versatility in signaling outcome is generated is not clear. In the Drosophila follicular epithelium, localized epidermal growth factor receptor (EGFR) activation induces distinct cell fates depending on its location. Posterior follicle cells respond to EGFR activity by expressing the T-box transcription factors Midline and H15, while anterior cells respond by expressing the homeodomain… CONTINUE READING

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