Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection.

@article{Miyoshi2009DeterminationOD,
  title={Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection.},
  author={Yurika Miyoshi and Kenji Hamase and Yosuke Tojo and Masashi Mita and Ryuichi Konno and Kiyoshi Zaitsu},
  journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences},
  year={2009},
  volume={877 24},
  pages={2506-12}
}
Two-dimensional-HPLC procedures have been established for the sensitive and selective determination of D-serine (D-Ser) and D-alanine (D-Ala), and their amounts in the tissues and physiological fluids of mice with various D-amino-acid oxidase (DAO) activities have been demonstrated. These two D-amino acids are modulators of the N-methyl-D-aspartate receptor mediated neurotransmission, and the alterations in their amounts following the changes in the DAO activity are matters of interest. After… CONTINUE READING

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These two D - amino acids are modulators of the N - methyl - D - aspartate receptor mediated neurotransmission , and the alterations in their amounts following the changes in the DAO activity are matters of interest .
These two D - amino acids are modulators of the N - methyl - D - aspartate receptor mediated neurotransmission , and the alterations in their amounts following the changes in the DAO activity are matters of interest .
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