Determination of Cloretazine (VNP40101M) and its active metabolite (VNP4090CE) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS).

Abstract

A sensitive method for the determination of Cloretazine (VNP40101M) and its metabolite (VNP4090CE) with an internal standard (ISTD) in human plasma was developed using high-performance liquid chromatographic separation with tandem mass spectrometric detection. Acidified plasma samples (500 microL) were prepared using solid phase extraction (SPE) columns… (More)

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@article{Bai2007DeterminationOC, title={Determination of Cloretazine (VNP40101M) and its active metabolite (VNP4090CE) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS).}, author={Feng Bai and Patton Minkin and Charles H Fraga and Melinda A O'Shaughnessy and Sridharan Gururangan and Clinton F Stewart}, journal={Journal of chromatography. B, Analytical technologies in the biomedical and life sciences}, year={2007}, volume={853 1-2}, pages={97-104} }