Determination of Brucine in Human Plasma by LC-MS/MS

  title={Determination of Brucine in Human Plasma by LC-MS/MS},
  author={Li Yan-xia},
A LC-MS/MS method was established for the determination of brucine in human plasma. A C18 column was used,with mobile phase of acetonitrile-0.2% formic acid(60:40). Aconitine was used as the internal standard. Electrospray ionization (ESI)source was applied and operated in positive ion mode. Multiple reaction monitoring (MRM) mode was used. The detected ions were m/z 395→324,263(brucine),m/z 646→586,526(aconitine). The calibration curve of brucine was linear in the concentration range of 4… CONTINUE READING

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