Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project.

  title={Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project.},
  author={David M. Greer and Sam D. Shemie and Ariane Lewis and Sylvia Torrance and Panayiotis N. Varelas and Fernando D. Goldenberg and James L. Bernat and Michael J. Souter and Mehmet Akif Topcuoglu and Anne W. Alexandrov and Marie R. Baldisseri and Thomas P Bleck and Giuseppe Citerio and Rosanne Dawson and Arnold Hoppe and Stephen J. Jacobe and Alex R Manara and Thomas A. Nakagawa and Thaddeus Mason Pope and William Silvester and David Thomson and Hussain N Al Rahma and Rafael Badenes and Andrew J. Baker and Vladim{\'i}r {\vC}ern{\'y} and Cherylee W. J. Chang and Tiffany Chang and Elena V. Gnedovskaya and Moon‐Ku Han and Stephen Honeybul and Edgar Jimenez and Yasuhiro Kuroda and Gang Liu and Uzzwal Kumar Mallick and Victoria Marquevich and Jorge Humberto Mejia-Mantilla and Michael A. Piradov and Sarah Quayyum and Gentle Sunder Shrestha and Yingying Su and Shelly D Timmons and J. Teitelbaum and Walter Videtta and Kapil G Zirpe and Gene Sung},
Importance There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally and within countries. Objective To formulate a consensus statement of recommendations on determination of BD/DNC based on review of the literature and expert opinion of a large multidisciplinary, international panel. Process Relevant international professional societies were recruited to develop recommendations regarding… 

Brain death/death by neurologic criteria determination: an update

This article gives an overview of recent changes and a practical update on diagnosis and definitions of brain death/DNC, and presents a short history of the concept and attempts to formulate uniform criteria.

Brain Death/Death by Neurologic Criteria Determination

The World Brain Death Project consensus statement is intended to provide guidance for professional societies and countries to revise or develop their own protocols on BD/DNC, taking into consideration local laws, culture, and resource availability; however, it does not replace local medical standards.

New perspectives on brain death

Questions remain regarding concepts such as ‘whole brain’ versus ‘brainstem’ death, and the intersection of BD/DNC and rubrics of medical futility, which are the subject of this review.

Pediatric brain death certification: a narrative review

It is the position that providers should endorse the criteria for brain death diagnosis in children as proposed by the Society of Critical Care Medicine, American Academy of Pediatrics, and Child Neurology Society, in order to prevent controversy and subjectivity surrounding what constitutes life versus death.

A review of current controversies in determining death by neurologic criteria in children

Ongoing research is needed to improve the safety of apnea testing and indications for and interpretation of ancillary testing, and objections to DNC, including issues of consent and requests for ongoing organ support.

Hitches to establish BD/DNC protocols to declare death in Africa

  • C. Machado
  • Political Science
    Frontiers in Drug, Chemistry and Clinical Research
  • 2021
Received: May 10, 2021; Accepted: May 20, 2021; Published: May 29, 2021 The World Brain Death Project addresses discrepancies in clinical guidelines across different countries and focuses attention

A Framework for Revisiting Brain Death: Evaluating Awareness and Attitudes Toward the Neuroscientific and Ethical Debate Around the American Academy of Neurology Brain Death Criteria

Although there is consistent support that AAN procedural criteria are best for clinical practice, results show a tenuous belief that these criteria determine irreversible and complete loss of all brain function.

Variability in Pediatric Brain Death Determination Protocols in the United States

Variability exists between pediatric institutional DNC protocols in all domains of DNC determination, especially with respect to apnea and ancillary testing, and better alignment of DNC protocols with national guidelines may improve the consistency and accuracy of DNC determined.

Minimum Criteria for Brain Death Determination: Consensus Promotion and Chinese Practice

The three-step QCP is of significant utility for ensuring accuracy and appropriateness in BDD and provides important evidence for advancing quality control for BDD in the next stage.



Brain death worldwide

There is uniform agreement on the neurologic examination with exception of the apnea test, however, this survey found other major differences in the procedures for diagnosing brain death in adults.

Evidence-based guideline update: Determining brain death in adults

There is insufficient evidence to determine the minimally acceptable observation period to ensure that neurologic functions have ceased irreversibly and if newer ancillary tests accurately confirm the cessation of function of the entire brain.

Determining brain death in adults

This document outlines diagnostic criteria for the chical diagnosis of brain death in patients older than 18 years and the sensitivity and specificity of laboratory tests that confirm the clinical diagnosis ofbrain death are discussed.

Variability of Brain Death Policies in the United States.

Hospital policies in the United States for the determination of brain death are still widely variable and not fully congruent with contemporary practice parameters, and hospitals should be encouraged to implement the 2010 AAN guidelines.

Brain death declaration

Substantial differences in perceptions and practices of brain death exist worldwide and the identification of discrepancies, improvement of gaps in medical education, and formalization of protocols in lower-income countries provide first pragmatic steps to reconciling these variations.

International guideline development for the determination of death

Introduction and MethodsThis report summarizes the results of the first phase in the development of international guidelines for death determination, focusing on the biology of death and the dying

Determination of death by neurologic criteria around the world

There is considerable variability in BD/DNC determination protocols around the world and it is recommended that a worldwide consensus be reached on the minimum standards for BD/ DNC.

Current controversies in brain death determination

It is argued that medical societies and governmental regulatory bodies must support the AAN criteria in order to decrease protocol variability, and must fully endorse the validity of these criteria as accepted medical standards.

Practice variability in brain death determination

There is a call for improved documentation, better uniformity of policies, and comprehensive and strategically targeted educational initiatives to ensure consistently contemporary approaches to BD determination in every patient.

Variability in Diagnosing Brain Death at an Academic Medical Center

The study shows wide variability in diagnosing brain death, which led us to update the authors' death by neurological criteria policy and increase awareness of brain death determination with the goal of improving their documentation following current AAN guidelines.